Journal article
An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania
Liyen Loh, Philippa M Saunders, Camilla Faoro, Neus Font-Porterias, Neda Nemat-Gorgani, Genelle F Harrison, Suraju Sadeeq, Luca Hensen, Shu Cheng Wong, Jacqueline Widjaja, E Bridie Clemens, Shiying Zhu, Katherine M Kichula, Sudan Tao, Faming Zhu, Gonzalo Montero-Martin, Marcelo Fernandez-Vina, Lisbeth A Guethlein, Julian P Vivian, Jane Davies Show all
Cell | Elsevier | Published : 2024
Abstract
Genetic variation in host immunity impacts the disproportionate burden of infectious diseases that can be experienced by First Nations peoples. Polymorphic human leukocyte antigen (HLA) class I and killer cell immunoglobulin-like receptors (KIRs) are key regulators of natural killer (NK) cells, which mediate early infection control. How this variation impacts their responses across populations is unclear. We show that HLA-A∗24:02 became the dominant ligand for inhibitory KIR3DL1 in First Nations peoples across Oceania, through positive natural selection. We identify KIR3DL1∗114, widespread across and unique to Oceania, as an allele lineage derived from archaic humans. KIR3DL1∗114+NK cells fr..
View full abstractRelated Projects (3)
Grants
Awarded by NIDDK NIH HHS
Awarded by NIAID NIH HHS